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Published on: April 28, 2015
Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic
Huaqing Zhang1, Yi Jin2, Cheng Chi2
1Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Sponge particulates offer unique properties for diverse biomedical uses, including drug delivery and tissue engineering. Recent advancements in preparation and bio-functionalization enhance their potential, even against SARS-CoV-2.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Engineering
Background:
- Sponge particulates possess advantageous properties like high porosity, elasticity, and a 3D reaction environment.
- Their unique structure serves as an excellent platform for drug delivery, tissue engineering, anti-infection, and wound healing applications.
- These particulates offer abundant reservoirs for cargo shielding and shuttling due to their broad surface and internal network.
Purpose of the Study:
- To review the unique physical properties and functions of sponge particulates in biomedical applications.
- To summarize current manufacturing techniques and bio-functionalization strategies for sponge particulates.
- To discuss the potential of sponge particulates in inhibiting SARS-CoV-2 infectivity and their future prospects.
Main Methods:
- Review of existing literature on sponge particulates in biomedicine.
- Analysis of optimized preparation techniques for controlling morphology and drug loading diversity.
- Examination of bio-functionalization strategies such as target modification, cell membrane camouflage, and hydrogel integration.
Main Results:
- Sponge particulates demonstrate significant potential in drug delivery, tissue engineering, and anti-infective therapies.
- Optimized preparation techniques simplify processes and improve reproducibility for sponge particulate fabrication.
- Bio-functionalization strategies effectively modulate properties and extend applications, including potential for SARS-CoV-2 inhibition.
Conclusions:
- Sponge particulates are versatile biomaterials with broad biomedical applications.
- Advancements in preparation and functionalization are key to unlocking their full potential.
- Further research into sponge particulates offers promising avenues for developing novel biomedicine, including combating viral infections.
