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Effect of heart rate on left ventricular longitudinal myocardial function in type 2 diabetes mellitus

Yuki Yamauchi1, Hidekazu Tanaka2, Shun Yokota1

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Cardiovascular Diabetology
|April 25, 2021
PubMed

Insights

High heart rate (HR) is linked to reduced heart function in type 2 diabetes mellitus (T2DM) patients. This finding suggests HR management may be important for T2DM cardiovascular health.

Area of Science:

  • Cardiology
  • Diabetology
  • Echocardiography

Background:

  • Left ventricular (LV) longitudinal myocardial dysfunction is a preclinical marker in type 2 diabetes mellitus (T2DM).
  • The impact of high heart rate (HR) on LV function in T2DM patients remains unclear.
  • Understanding this relationship is crucial for managing cardiovascular risk in T2DM.

Purpose of the Study:

  • To investigate the association between high heart rate (HR) and LV longitudinal myocardial function in T2DM patients.
  • To determine if HR is an independent predictor of subclinical LV dysfunction in T2DM.
  • To provide insights into T2DM patient management.

Main Methods:

  • Studied 192 T2DM patients and 81 healthy volunteers with preserved LV ejection fraction (LVEF).
  • Assessed LV longitudinal myocardial function using global longitudinal strain (GLS), with GLS < 18% indicating subclinical dysfunction.
  • Defined high HR as resting HR ≥ 70 beats/minute and analyzed associations using multivariable logistic regression.

Main Results:

  • T2DM patients with high HR exhibited significantly lower GLS compared to those with low HR (16.3% vs. 17.8%, P=0.03).
  • High HR was independently associated with subclinical LV dysfunction (GLS < 18%) in T2DM patients (OR=1.04, P=0.01).
  • The predictive model for subclinical LV dysfunction improved with the addition of LVEF, E/e', and high HR.

Conclusions:

  • Resting heart rate is associated with LV longitudinal myocardial function in asymptomatic T2DM patients with preserved LVEF.
  • High HR independently predicts subclinical LV dysfunction in T2DM.
  • Findings offer new perspectives for T2DM management, emphasizing potential benefits of HR control.
Abstract

Keywords:
EchocardiographyGlobal longitudinal strainHeart rateType 2 diabetes mellitus

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