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Published on: October 22, 2015
Improving intraoperative evoked potentials at short latency by a novel neuro-stimulation technology with delayed
Johannes Sarnthein1, Michael Tomilov2, Matthias Baag2
1Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland; Klinisches Neurowissenschaften Zentrum, Universität Zürich, Switzerland.
Objective:
The intraoperative monitoring of cranial nerve function records evoked responses at latencies of a few milliseconds. Unfortunately, these responses may be masked by the electrical artifact of the stimulation pulse. In electrical stimulation, the return discharge of the stimulation pulse significantly contributes to the width of the electrical artifact.
Methods:
We have generated stimulation pulses with an ISIS Neurostimulator (inomed Medizintechnik GmbH) providing a novel stimulation artifact reduction technique. It delays the return discharge of the stimulating pulse beyond the latency of the expected physiological response. This delayed return discharge is controlled such that no unintended physiological response is evoked.
Results:
In 21 neurosurgical interventions with motor evoked potentials of the facial nerve (FNMEP), the stimulation method generated a stimulation pulse artifact with reduced tail duration. Compared to conventional stimulation with immediate return discharge, the signal-to-noise ratio of the physiological response may improve with the novel stimulation method. In some surgeries, only the novel stimulation method generated clearly identifiable response signals.
Conclusions:
The reduced width of the stimulation artifact extends the toolbox of intraoperative monitoring modalities by rendering the interpretation of cranial nerve evoked potentials more reliable.
Significance:
The novel technique enhances the number of patients for whom intraoperative monitoring may aid in cranial neurosurgery.
