Genome-wide genotype-phenotype associations in microbes
Related Experiment Video
Updated: Nov 8, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Huibao Feng1, Yaomeng Yuan1, Zheng Yang2
1MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Abstract:
The concept of a gene has been developed a lot since the Mendelian era owing to the rapid progress in molecular biology and informatics. To explore the nature of life, varieties of biological tools have been continuously established. Many achievements have been made to clarify the relationships between genotypes and phenotypes. However, it is still not completely clear that how traits of an organism are encoded by its genome. In this review, we will summarize and discuss representative works in systematical functional genomic studies in microbes. By analyzing their developmental progressions and limitations, we may have chances to design more powerful means to decipher the code of life.
Related Concept Videos
Modern Molecular Taxonomy
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Genomic DNA in Prokaryotes
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genetic Lingo
Bacterial Phylum Tenericutes

