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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
How NS1 Antibodies Prevent Severe Flavivirus Disease
Justin S G Ooi1, Shee-Mei Lok2
1Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Abstract:
The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.

