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Controlling drug release with additive manufacturing-based solutions.

Shriya K Patel1, Mouhamad Khoder2, Matthew Peak3

  • 1Institute of Pharmaceutical Science, King's College London, London, UK.

Advanced Drug Delivery Reviews
|April 25, 2021
PubMed
Summary

3D printing (additive manufacturing) offers novel ways to create personalized medicines with controlled drug release. This review explores 3D printing technologies, materials, and methods for optimizing drug delivery from printed dosage forms.

Keywords:
EntericFDMFFFImmediateMatrixPowderSLASLSSemi-solid extrusionSurface-to-mass ratio

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery

Background:

  • 3D printing (additive manufacturing) is an innovative technology with potential to revolutionize solid dosage forms.
  • It offers advantages over conventional methods, including rapid prototyping and fabrication of complex geometries.
  • This technology can enable personalized dosage forms with well-defined release profiles.

Purpose of the Study:

  • To review the current state of additive manufacturing for predicting and understanding drug release from 3D printed structures.
  • To describe various 3D printing technologies, materials, procedures, and parameters used for fabricating drug matrices.
  • To evaluate methods for manipulating drug release patterns and discuss relevant drug release mechanisms and models.

Main Methods:

  • Review of additive manufacturing technologies (e.g., fused deposition modeling, stereolithography).
  • Analysis of materials used in 3D printing for pharmaceutical applications.
  • Evaluation of methods to control drug release, including surface area-to-mass ratio, infill patterns, geometry, and composition.

Main Results:

  • Additive manufacturing enables the creation of complex dosage form geometries for tailored drug release.
  • Various 3D printing parameters significantly influence drug release kinetics.
  • Different printing materials and designs offer diverse strategies for controlling drug elution.

Conclusions:

  • 3D printing holds significant promise for developing personalized medicines with predictable drug release.
  • Understanding the interplay between printing parameters, material properties, and dosage form design is crucial for optimizing drug delivery.
  • Technical and regulatory challenges need to be addressed for the widespread adoption of 3D printed pharmaceuticals.