Related Experiment Video
Updated: Nov 8, 2025
14:43
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
12.3K
Next generation strategies for preventing preterm birth.
Hannah C Zierden1, Rachel L Shapiro1, Kevin DeLong2
1Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Advanced Drug Delivery Reviews
|April 25, 2021
Summary
Preterm birth prevention faces challenges as Makena may lose FDA approval. New interdisciplinary research aims to identify risks and develop novel therapies to save infant lives.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Biomedical Engineering
Background:
- Preterm birth (PTB) affects 15 million infants globally, increasing mortality and lifelong health issues.
- The U.S. currently has limited FDA-approved therapies for PTB prevention, with Makena facing potential withdrawal.
- Lack of effective treatments necessitates urgent development of new therapeutic options.
Purpose of the Study:
- To address the critical need for effective preterm birth prevention strategies.
- To explore interdisciplinary approaches for understanding PTB.
- To develop next-generation therapies for preventing premature labor.
Main Methods:
- Interdisciplinary collaboration involving physicians, pharmacologists, biologists, chemists, and engineers.
- Investigating risk factors and underlying mechanisms of preterm birth.
- Developing novel therapeutic interventions for PTB prevention.
Main Results:
- Advances in understanding PTB risk factors and mechanisms.
- Development of potential next-generation therapies.
- Improved identification of at-risk pregnancies.
Conclusions:
- Interdisciplinary research is crucial for advancing PTB prevention.
- Novel therapies hold promise for reducing premature labor onset.
- These efforts aim to significantly decrease infant mortality and improve outcomes.
Related Concept Videos
01:22Birth Control Methods
5.4K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.4K
01:30Preventive Healthcare Services
1.2K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.2K
01:26Levels of Health Promotion and Illness Prevention
13.8K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
13.8K
01:22Healthcare Associated Infections II: Preventive Measures
3.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.4K
01:30Pneumonia V: Nursing management and Prevention
2.9K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.9K
01:29Venous Thrombosis III: Interprofessional Care
91
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
91