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[Uric acid in children and adolescents with primary hypertension]

Michał Szyszka1, Piotr Skrzypczyk2, Małgorzata Pańczyk-Tomaszewska2

  • 1Medical University of Warsaw, Poland: Doctoral School, Department of Pediatrics and Nephrology.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|April 25, 2021
PubMed

Insights

Children with primary hypertension (PH) have higher uric acid levels than healthy children. Male sex and higher body weight are key risk factors for elevated uric acid in pediatric PH patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Metabolic Disorders

Background:

  • Elevated serum uric acid is implicated in primary hypertension (PH) pathogenesis.
  • Understanding uric acid levels in pediatric PH is crucial for early intervention.

Purpose of the Study:

  • To assess serum uric acid concentration in children with PH.
  • To investigate correlations between uric acid and clinical/biochemical parameters in pediatric PH.

Main Methods:

  • Study included 57 children with PH and 20 healthy controls.
  • Assessed serum uric acid, blood pressure (office and 24-hour ABPM), and biochemical markers.
  • Multivariate analysis identified determinants of uric acid concentration.

Main Results:

  • Children with PH exhibited significantly higher serum uric acid than controls (5.72 vs. 4.55 mg/dL).
  • Uric acid levels were higher in boys than girls with PH.
  • Uric acid correlated positively with age, height, weight, BMI, neutrophils, systolic BP, and pulse pressure; negatively with HDL, heart rate, and nighttime diastolic BP dip.

Conclusions:

  • Pediatric PH patients demonstrate increased serum uric acid concentrations.
  • Male sex and elevated body weight are significant risk factors for hyperuricemia in pediatric PH.

Keywords:
adolescentschildrenprimary hypertensionuric acid

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