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Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
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Renal Tissue Damage Induced by Acute Kidney Injury in Sepsis Rat Model Is Inhibited by Cynaropicrin via IL-1β and

Danlei Cai1, Hongdan Duan2, Yangshan Fu2

  • 1Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Doklady. Biochemistry and Biophysics
|April 25, 2021
PubMed

Insights

Cynaropicrin effectively treats acute kidney injury (AKI) in rats by reducing kidney damage and improving survival rates. This sepsis-induced complication is mitigated through reduced inflammation and apoptosis.

Area of Science:

  • Nephrology
  • Pharmacology
  • Immunology

Background:

  • Sepsis-induced acute kidney injury (AKI) is a severe complication with high morbidity and mortality.
  • Current therapeutic options for AKI are limited, necessitating the exploration of novel treatments.

Purpose of the Study:

  • To investigate the protective effects of cynaropicrin against sepsis-induced AKI in a rat model.
  • To elucidate the underlying mechanisms of cynaropicrin's renoprotective action.

Main Methods:

  • Rats were subjected to sepsis to induce AKI.
  • Cynaropicrin was administered at varying doses to assess its therapeutic potential.
  • Serum markers (urea nitrogen, creatinine), inflammatory cytokines (IL-1β, TNF-α), and apoptosis-related proteins (Bax, Bcl-2) were analyzed.
  • Survival rates were monitored.

Main Results:

  • Cynaropicrin treatment significantly reduced serum urea nitrogen and creatinine levels in a dose-dependent manner.
  • Renal injury and inflammation, indicated by decreased IL-1β and TNF-α secretion, were ameliorated by cynaropicrin.
  • Cynaropicrin modulated apoptosis by decreasing Bax expression and increasing Bcl-2 expression.
  • Survival rates in rats with AKI were significantly improved following cynaropicrin treatment.

Conclusions:

  • Cynaropicrin demonstrates significant renoprotective effects in a sepsis-induced AKI rat model.
  • The therapeutic mechanism involves the suppression of inflammatory cytokine secretion and the modulation of apoptosis.
  • Cynaropicrin holds potential as a therapeutic agent for treating acute kidney injury.
Keywords:
acute kidney injurychemotherapycynaropicrininflammationsepsis

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