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Toxic proteins application in cancer therapy

Zahra Setayesh-Mehr1, Mahdiye Poorsargol2

  • 1Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran. setayeshmehr@uoz.ac.ir.

Molecular Biology Reports
|April 25, 2021
PubMed

Insights

Ribosome inactivating proteins (RIPs) are promising anti-cancer drugs that overcome drug resistance. This review explores challenges and advances in delivering RIPs, like trichosanthin and gelonin, to tumor cells for effective cancer therapy.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Ribosome inactivating proteins (RIPs) show potential as anti-cancer agents.
  • RIPs utilize a large-size effect (LSE) to bypass drug resistance transporters (DRTs).
  • Clinical application of RIPs is hindered by delivery challenges to tumor cells.

Purpose of the Study:

  • To review RIPs, focusing on trichosanthin (TCS) and gelonin (Gel).
  • To identify bio-barriers encountered by RIPs in cancer therapy.
  • To highlight advancements in RIP delivery strategies for cancer treatment.

Main Methods:

  • Literature review of RIPs, including natural and scorpion venom-derived types.
  • Analysis of drug resistance mechanisms and bio-barriers affecting RIPs.
  • Exploration of current state-of-the-art delivery systems for RIPs.

Main Results:

  • RIPs offer a unique mechanism against drug-resistant cancers.
  • Key bio-barriers include cellular uptake and tumor penetration.
  • Novel delivery systems are emerging to enhance RIP efficacy.

Conclusions:

  • Overcoming delivery obstacles is crucial for RIPs in clinical cancer therapy.
  • Further research into targeted delivery systems will improve RIP-based treatments.
  • RIPs represent a valuable class of therapeutics for overcoming drug resistance.
Keywords:
CancerCytotoxicityDrug deliveryProteinsScorpion venomTumor

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