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Functional Immunostimulating DNA Materials: The Rising Stars for Cancer Immunotherapy
Ziwen Dai1,2, Lei Wang1, Zhigang Wang3
1College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518055, China.
Abstract:
Cancer immunotherapy has risen as a promising method in clinical practice for cancer treatment and DNA-based immune intervention materials, along with DNA nanotechnology, have obtained increasing importance in this field. In this review, various immunostimulating DNA materials are introduced and the mechanisms via which they exerted an immune effect are explained. Then, representative examples in which DNA is used as the leading component for anticancer applications through immune stimulation are provided and their efficacy is evaluated. Finally, the challenges for those materials in clinical applications are discussed and suggestions for possible further research directions are also put forward.
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