Related Experiment Video
Updated: Nov 8, 2025
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Correlation analysis between expression of histone deacetylase 6 and clinical parameters in IgA nephropathy patients
Yan Hu1, Minghua Shang2, Yingfeng Shi1
1Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Insights
High levels of histone deacetylase 6 (HDAC6) indicate kidney dysfunction in IgA nephropathy (IgAN) patients. This suggests HDAC6 may be a biomarker for disease progression in IgAN.
Area of Science:
- Nephrology
- Molecular Biology
- Biochemistry
Background:
- Histone deacetylase 6 (HDAC6) is implicated in experimental kidney disease models.
- The clinical significance of HDAC6 in IgA nephropathy (IgAN) remains unclear.
Purpose of the Study:
- To investigate the correlation between HDAC6 expression and clinical parameters in IgA nephropathy (IgAN) patients.
Main Methods:
- Analysis of 46 IgAN kidney biopsy specimens and 7 normal renal cortex tissues.
- Examined the relationship between HDAC6 expression and various clinical and pathological indicators.
Main Results:
- HDAC6 was significantly upregulated in IgAN patients compared to controls, with decreased acetyl histone H3.
- HDAC6 expression correlated with renal function markers (eGFR, serum creatinine, cystatin C) and Oxford Classification.
- HDAC6 levels increased as estimated glomerular filtration rate (eGFR) decreased.
Conclusions:
- Elevated HDAC6 expression in IgAN is associated with impaired kidney function.
- HDAC6 may serve as a potential biomarker for renal dysfunction in IgAN.
Background:
It has been demonstrated that histone deacetylase 6 (HDAC6) is involved in various kidney diseases in experimental study. However, correlation between HDAC6 and clinical parameters in IgA nephropathy (IgAN) patients is still unknown.
Methods:
A total of 46 human kidney biopsy specimens with IgAN were selected as observation group, specimens of normal renal cortex tissue that was not affected by the tumor from patients with renal carcinoma (n = 7) served as control. We investigated the relationship between HDAC6 and clinical parameters in IgAN.
Results:
HDAC6 was highly expressed in human kidney biopsy specimens with IgAN compared with control group, while the number of acetyl histone H3 positive cells were significantly decreased. There was a statistical difference in the indexes of albumin, estimated glomerular filtration rate (eGFR), serum urea, serum creatinine, serum uric acid, β2-microglobulin, cystatin C, cholesterol, high-density lipoprotein, low-density lipoprotein, and HDAC6 positive area among the different Oxford Classification (p < 0.05). The expression of HDAC6 was different in various eGFR levels, the expression of HDAC6 increased with the decreasing of eGFR level, the expression of acetyl histone H3 decreased with the decreasing of eGFR level. In addition, the expression of HDAC6 positively correlated with Masson trichrome positive area, serum urea, serum creatinine, β2 macroglobulin, and cystatin C, while negatively correlated with eGFR and acetyl histone H3. Multivariate linear regression analysis demonstrated that eGFR and cystatin C were independently associated with HDAC6, respectively (p < 0.05).
Conclusions:
These results suggested that high level of HDAC6 expression in IgAN is correlated with renal dysfunction.
