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Updated: Nov 8, 2025
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
Published on: October 17, 2016
Cytocompatible scaffolds of poly(L-lactide)/reduced graphene oxide for tissue engineering
Esperanza Díaz1,2, Naroa Iglesias1, Sylvie Ribeiro3,4
1Escuela de Ingeniería de Bilbao, Departamento de Ingeniería Minera, Metalúrgica y Ciencia de Materiales, Universidad del País Vasco (UPV/EHU), Portugalete, Spain.
Abstract:
Poly(L-lactide)/reduced graphene oxide (PLLA/rGO) scaffolds were studied in the present work. The scaffolds were fabricated by TIPS (thermally induced phase separation). Nonisothermal crystallization study for PLLA/rGO was investigated and revealed the nucleating effect of rGO. rGO effect on cytotoxicity, thermal properties, and hydrolysis resistance of PLLA and PLLA/rGO scaffolds were analysed. In vitro degradation in phosphate-buffered solution at 37 °C is analyzed over twelve weeks. A high crystalline behaviour reduces the speed of hydrolysis and therefore implies less variation in pH, mass loss and water up take. The rGO does not seem to accelerate the degradation process. Finally, rGO contents in PLLA up to 1 wt% dos not lead to cytotoxic effect, the scaffolds supporting cell adhesion and proliferation.
