Highly integrated CMOS microsystems to interface with neurons at subcellular resolution.

Area of Science:

• Neuroscience
• Biomedical Engineering
• Signal Processing

Background:

• Established neuroscientific methods struggle to access axonal signaling.
• Monitoring large neuronal networks over extended periods is challenging.

Purpose of the Study:

• To introduce CMOS high-density transducer arrays for novel neuroscientific insights.
• To enable investigation of axonal signaling characteristics.
• To facilitate high-throughput, long-term monitoring of neuronal networks.

Main Methods:

• Utilizing CMOS (complementary metal-oxide-semiconductor) high-density transducer arrays.
• Investigating axonal signaling characteristics.
• Performing high-throughput monitoring of action potentials in neuronal networks (>1000 neurons).

Main Results:

• CMOS arrays provide access to previously inaccessible axonal signaling.
• High-throughput monitoring of action potentials in large neuronal networks is achieved.
• Extended time-series data collection for developmental studies or disturbance effects is enabled.

Conclusions:

• CMOS high-density transducer arrays represent a significant advancement in neuroscientific research tools.
• These arrays facilitate novel investigations into neuronal function and network dynamics.
• Applications span research in neural diseases and pharmacology, offering new avenues for discovery.