Related Experiment Video
Updated: Nov 8, 2025
13:08
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
9.1K
Impaired Emotional Self-Referential Processing in First-Episode Schizophrenia.
Yanli Zhao1, Zhiren Wang1, Yueyao Zhang2
1Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University Huilonguan Clinical Medical School, Beijing, China.
Frontiers in Psychiatry
|April 26, 2021
Summary
Schizophrenia patients show impaired self-representation, particularly for familiar others. Brain activity reveals differences in memory processing and attention, indicating altered self-referential cognition in early psychosis.
Area of Science:
- Cognitive Neuroscience
- Psychiatry
- Neuroimaging
Background:
- Self-representation impairments are linked to psychosis.
- Neural mechanisms of self-impairment in schizophrenia are not well understood.
Purpose of the Study:
- Investigate self-representation deficits in first-episode schizophrenia.
- Examine neural correlates using event-related potentials (ERPs).
Main Methods:
- Compared 56 schizophrenia patients and 56 controls.
- Used ERPs to measure brain activity during self-referential adjective judgment and recognition tasks.
- Analyzed P2 and late positive potential (LPP) amplitudes.
Main Results:
- Schizophrenia patients had lower recognition for mother-referential adjectives compared to self-referential ones.
- Controls showed typical self-reference effects; patients did not.
- Patients exhibited enhanced LPP for positive words during retrieval, unlike controls.
Conclusions:
- First-episode schizophrenia involves self-representation dysfunction, especially concerning intimate others.
- Absence of a negative memory bias in patients.
- Altered neural processing of self-related information in early psychosis.
Related Concept Videos
01:30Negative and Cognitive Symptoms of Schizophrenia
175
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
175
01:17Schizophrenia
414
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
414
01:29Psychological and Sociocultural Causes of Schizophrenia
261
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
261
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
260
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
260
01:20Personality Disorders: Schizotypal and Histrionic
221
Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
221
01:22Personality Disorders: Paranoid and Schizoid
260
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Paranoid Personality Disorder
Paranoid personality disorder is...
260