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Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.

Estelle A Cuttaz1, Christopher A R Chapman1, Omaer Syed1

  • 1Department of Bioengineering Imperial College South Kensington London SW7 2AZ UK.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 26, 2021
PubMed
Summary
This summary is machine-generated.

New conductive elastomers (CEs) offer reliable, flexible bioelectronic nerve cuffs. These polymer devices demonstrate stable performance and superior electrochemical properties for clinical applications.

Keywords:
conductive elastomerconductive polymerelectrode characterizationflexible bioelectronicslaser manufacturingperipheral nerve cuff

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Flexible polymer bioelectronics require clinical translation through reliable fabrication and stable performance.
  • Conductive elastomers (CEs) combine conductive polymers and elastomeric matrices for enhanced flexibility and electrochemical properties over metallic electrodes.

Purpose of the Study:

  • To develop and assess nerve cuff devices using conductive elastomers (CEs) from material to electrode array stages.
  • To compare the performance and stability of CE nerve cuffs against state-of-the-art metallic nerve cuffs.

Main Methods:

  • Fabrication of two CE cuff types via laser machining on polydimethylsiloxane substrates.
  • Lamination into pre-curled tubing for cuff formation.
  • Evaluation of device performance, stability (sterilization, mechanical loading), charge transfer, and electrochemical safety ex vivo.

Main Results:

  • CE nerve cuffs exhibited electrical and mechanical stability.
  • Improved charge transfer properties were observed in CE cuffs compared to commercial metallic cuffs.
  • CE cuffs demonstrated superior charge transfer and electrochemical safety in ex vivo sciatic nerve application.

Conclusions:

  • Conductive elastomers are promising for reliable and stable flexible polymer bioelectronic nerve cuff devices.
  • CE nerve cuffs offer enhanced electrochemical performance and safety for neural interfacing.
  • This work supports the clinical transition of advanced bioelectronic technologies.