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Updated: Nov 8, 2025
Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
An overview of polyester/hydroxyapatite composites for bone tissue repairing
Zeyu Fu1,2, Jinjie Cui1, Bin Zhao2
1Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
Polyester/hydroxyapatite (polyester/HA) composites are promising for bone repair due to their biomimetic properties. This review covers their geometries, applications, and future development trends in bone tissue engineering.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Orthopedic Research
Background:
- Polyester/hydroxyapatite (polyester/HA) composites mimic natural bone, making them vital for bone tissue repair.
- Their composition and structure closely resemble mineralized bone tissue.
Purpose of the Study:
- To review common geometries of polyester/HA composites (microspheres, membranes, scaffolds, bulks).
- To discuss their applications in bone tissue repair.
- To identify current limitations and future development trends for polyester/HA composites.
Main Methods:
- Literature search conducted on Web of Science and Google Scholar for polyester/HA composite studies.
- Analysis focused on fabrication techniques, mechanical, biodegradable, and biological properties.
- Evaluation of applications in bone repair.
Main Results:
- 111 articles reviewed, discussing various polyester/HA composite geometries.
- Hydroxyapatite addition modifies mechanical and biodegradable properties of polyesters.
- Hydroxyapatite enhances osteogenic capabilities, indicating suitability for bone repair.
Conclusions:
- Polyester/HA composites exhibit excellent mechanical strength, biodegradability, and biological properties.
- Diverse geometries are utilized in bone repair, drug delivery, and implant fixation.
- Future research should address controlled degradation, drug release, mechanical matching, and novel fabrication.
