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Related Experiment Videos

Quantitative bacterial flora of acute appendicitis.

J P Roberts1

  • 1Department of Microbiology, Southampton General Hospital.

Archives of Disease in Childhood
|May 1, 1988
PubMed
Summary

Bacterial counts in normal and inflamed appendix walls showed no significant differences in children. This suggests bacterial infection is unlikely to be the primary cause of appendicitis.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Pediatric Surgery

Background:

  • Appendicitis is a common surgical emergency in children.
  • The role of bacterial infection in appendicitis pathogenesis is debated.
  • Previous studies have yielded conflicting results on appendix flora.

Purpose of the Study:

  • To quantitatively assess the bacterial flora in histologically normal and inflamed appendices in children.
  • To determine if bacterial proliferation correlates with acute appendicitis.
  • To investigate the etiological role of bacteria in appendicitis.

Main Methods:

  • A quantitative bacteriological analysis of appendix wall tissue was performed.
  • 43 pediatric patients admitted for appendicitis were included.
  • Bacterial counts were compared between normal and inflamed appendix samples.

Main Results:

  • No significant differences in bacterial flora were observed between normal and inflamed appendices.
  • Common organisms included Bacteroides, Escherichia coli, and streptococci (10^3-10^8 CFU/g).
  • Bacteroides species were frequently the dominant flora in both groups.

Conclusions:

  • The similar bacterial load in normal and inflamed appendices suggests appendicitis is not primarily caused by bacterial overgrowth.
  • An unfavorable environment for bacterial proliferation may exist in inflamed appendices.
  • Primary bacterial infection is unlikely to be the etiological factor in appendicitis pathogenesis.

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