Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older-Age Bipolar Disorder ISBD Task Forces.

Bipolar disorders·2026
Same author

Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Spinal cord imaging for multiple sclerosis: Advances, priorities, and opportunities.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Myelin damage in radiologically isolated syndrome is associated with decreased processing speed.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

Increased PET <sup>11</sup>C-PBR28 binding in multiple sclerosis normal-appearing white matter correlates with MRI measures of myelin loss.

Multiple sclerosis and related disorders·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Nov 8, 2025

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

614

Myelin water fraction decrease in individuals with chronic mild traumatic brain injury and persistent symptoms.

Bretta Russell-Schulz1, Irene M Vavasour1, Jing Zhang2

  • 1UBC MRI Research Centre, Department of Radiology, University of British Columbia, Vancouver, BC, Canada.

Heliyon
|April 26, 2021
PubMed
Summary

Mild traumatic brain injury (mTBI) is linked to reduced myelin water fraction (MWF) in white matter, impacting brain structure long-term. This study found lower MWF in chronic mTBI patients, but no direct correlation with cognitive performance.

Keywords:
Chronic injuryCognitionMagnetic resonance imagingMild traumatic brain injuryMyelin water fraction

More Related Videos

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
04:54

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

790
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.4K

Related Experiment Videos

Last Updated: Nov 8, 2025

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

614
Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
04:54

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

790
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.4K

Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Mild traumatic brain injury (mTBI) can cause persistent symptoms, complicating the assessment of brain-behavior relationships due to evolving secondary changes.
  • Myelin integrity is crucial for cognitive function, and its alterations may underlie long-term deficits after brain injury.

Purpose of the Study:

  • To investigate white matter integrity using myelin water imaging in individuals with chronic mTBI and persistent symptoms.
  • To assess the relationship between myelin water fraction (MWF) and cognitive status in this population.

Main Methods:

  • Utilized myelin water imaging to quantify myelin water fraction (MWF) in the white matter of participants.
  • Administered the NIH Toolbox Cognitive Battery to measure cognitive functioning.
  • Compared MWF and cognitive data between 15 adults with chronic mTBI and 12 healthy controls.

Main Results:

  • A significant global decrease in white matter MWF was observed in individuals with chronic mTBI compared to healthy controls.
  • Reduced MWF was found in multiple white matter regions, including the corpus callosum, superior longitudinal fasciculus, and corticospinal tract.
  • Despite lower cognitive functioning in mTBI patients, no significant correlation was found between MWF and cognitive measures.

Conclusions:

  • Chronic mild traumatic brain injury with persistent symptoms is associated with reduced white matter myelin integrity, as indicated by decreased MWF.
  • While myelin damage is evident, its direct correlation with cognitive deficits in this chronic mTBI cohort requires further investigation.