Related Experiment Video
Updated: Nov 8, 2025
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Dietary inflammatory potential is associated with poor periodontal health: A population-based study
An Li1, Yuntao Chen2, Annemarie A Schuller1,3
1Center for Dentistry and Oral Hygiene, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands.
Aim:
To investigate the association between dietary inflammatory potential and poor periodontal health.
Material And Methods:
A cross-sectional analysis of a nationally representative sample of participants was performed. NHANES 2011-2014 (n = 7081) and NHANES 2001-2004 (n = 5098) were used as discovery and validation datasets, respectively. The energy-adjusted dietary inflammatory index (E-DII) score was calculated for each participant based on 24-h dietary recalls to assess diet-associated inflammation. Periodontitis was defined by the CDC/AAP using clinical periodontal parameters. Natural cubic spline was applied to identify any non-linear associations of the E-DII score with moderate/severe periodontitis. Furthermore, interaction analyses were performed by age, gender, and race/ethnicity to explore the moderating roles of these factors.
Results:
In the discovery dataset, a non-linear positive relationship with periodontitis was identified for the E-DII score (pnon-linearity < .001) after adjustment for potential confounders. Compared with those individuals in the lowest tertile of E-DII, participants in the highest tertile who consumed a pro-inflammatory diet were 53% more likely to be periodontitis (OR tertile3vs1 = 1.53, 95% CI: 1.33-1.77). The validation dataset showed similar associations. Relatively stronger associations were seen in older adults and males.
Conclusion:
Consuming a pro-inflammatory diet indicated by the E-DII score is associated with periodontal disease in the U.S. general adult population.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...