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Updated: Nov 8, 2025

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
Current markers for infertility in men
Jéssica Alves Magalhães1, Larissa Sousa Ribeiro1,2, João Paulo Arcelino Rego2
1Laboratory of Translational Research, Christus University (UNICHRISTUS), Fortaleza, CE, Brazil.
Abstract:
Male infertility accounts for about 30% of the causes of couple infertility and has become a public health concern. Male infertility may be caused by several factors occurring in isolation or association with several complex syndromes. Despite the importance of semen analysis in the initial investigation of infertility, it has been estimated that 15% of infertile men present normal sperm, a proportion that calls for additional tests to further investigate cases of infertility and accurately determine the factors that alter ejaculate quality. In addition to semen analysis parameters, genetics has been drawing attention. The incorporation of genetic diagnostic methods in the routine practice of andrology laboratories is an important step to further improve assisted reproductive technologies. The present study described the current status of the main methods used in male infertility investigation.
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