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In Vitro Drug Release Testing: Overview, Development and Validation

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Related Experiment Video

Updated: Nov 8, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Resources for Developing Reliable and Reproducible In Vitro Toxicological Test Methods.

Elijah J Petersen¹, Vytautas Reipa¹, Menghang Xia²

¹Biosystems and Biomaterials Division, Material Measurement Laboratory, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.

Chemical Research in Toxicology

|April 26, 2021

Summary

New resources and tools enhance the reliability and reproducibility of in vitro toxicological testing. These advancements offer advantages over traditional in vivo methods.

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Area of Science:

Toxicology
Biotechnology
Laboratory Science

Background:

In vitro test methods offer potential advantages over in vivo studies.
Developing reliable and reproducible in vitro assays is crucial for toxicological assessments.

Purpose of the Study:

To describe key resources and tools for improving in vitro test methods.
To enhance the reliability and reproducibility of toxicological testing.

Main Methods:

Literature review of existing resources and tools.
Description of methodologies for in vitro assay validation.

Main Results:

Identification of key resources and tools.
Demonstration of methods to improve assay consistency.

Conclusions:

Available resources and tools can significantly enhance in vitro toxicology.
Increased reliability and reproducibility of in vitro methods are achievable.