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Updated: Nov 8, 2025

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Patient Release and Instructions for Lutetium Dotatate Radiopharmaceutical Therapy
James Underwood, Glenn Sturchio1, Susan Arnold2
1Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
Lutetium Dotatate (Lutathera) therapy for neuroendocrine tumors can be safely administered on an outpatient basis. This study provides guidelines to ensure patient radiation exposure remains within safe limits for public health.
Area of Science:
- Nuclear medicine
- Oncology
- Radiopharmaceutical therapy
Background:
- Lutetium Dotatate (Lutathera) is an FDA-approved radiopharmaceutical for treating somatostatin receptor-positive neuroendocrine tumors.
- Radiopharmaceutical therapies require careful management of patient radiation exposure to protect the public.
Purpose of the Study:
- To demonstrate the feasibility of outpatient administration for Lutetium Dotatate therapy.
- To establish safety and travel guidelines for patients receiving Lutetium Dotatate to enable outpatient treatment.
Main Methods:
- Analysis of radiation exposure from Lutetium Dotatate administration.
- Development of patient safety and travel restriction protocols.
Main Results:
- Lutetium Dotatate therapy can be safely administered on an outpatient basis.
- Established guidelines ensure radiation exposure to the public remains within regulatory limits.
Conclusions:
- Outpatient Lutetium Dotatate therapy is a viable treatment option for neuroendocrine tumors.
- Implementing provided safety and travel restrictions facilitates safe outpatient radiopharmaceutical treatment.
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