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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Revising nerve conduction reference limits.

Sanjeev D Nandedkar^1,2, Khushnuma Mansukhani³, Nandini More³

¹Natus Medical Inc, Hopewell Junction, New York, USA.

|April 26, 2021

Summary

This summary is machine-generated.

New reference limits (RL) for nerve conduction studies were derived using extrapolated reference value (ERef) and multi-variable extrapolated reference value (MeRef) methods. These updated RL improve specificity for latency and velocity measurements in adult patients.

Keywords:

E-ref MeRef aging height nerve conduction study normal values

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Area of Science:

Neurophysiology
Clinical Electrophysiology

Background:

Current reference limits (RL) for electrodiagnostic laboratories are often decades old.
Advancements in instrumentation and techniques necessitate re-evaluation of existing RL.
Demographic-based RL can enhance diagnostic accuracy.

Purpose of the Study:

To validate and revise current laboratory reference limits (RL) for motor nerve conduction studies.
To explore the utility of extrapolated reference value (ERef) and multi-variable extrapolated reference value (MeRef) methods for establishing updated RL.
To investigate the influence of patient demographics on nerve conduction parameters.

Main Methods:

Analysis of latency and velocity data from 740 adult patients undergoing motor nerve conduction studies.
Derivation of RL using ERef and MeRef methodologies.
Correlation analysis of nerve conduction parameters with patient age and height.

Main Results:

ERef limits for median and ulnar nerve latency were similar to current RL, while tibial and fibular nerve latency limits were slightly shorter.
Ulnar nerve conduction velocity showed no dependence on age or height, with ERef matching current RL.
Median, tibial, and fibular nerve conduction velocities demonstrated age and/or height-dependent decreases.

Conclusions:

ERef and MeRef methods are effective for validating and revising nerve conduction study RL.
Updated RL, incorporating demographic factors via MeRef for velocity analysis, will enhance diagnostic specificity.
The study supports the adoption of revised RL for improved electrodiagnostic practice.