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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

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Case Series of Laboratory-Associated Zika Virus Disease, United States, 2016-2019

Susan L Hills, Andrea Morrison, Shawna Stuck

    Emerging Infectious Diseases
    |April 26, 2021
    PubMed

    Insights

    Laboratory researchers face Zika virus exposure risks. Four US laboratory-associated cases occurred from 2016-2019, with two from needlestick injuries. Strict biosafety practices are crucial for preventing Zika virus infection in labs.

    Area of Science:

    • Virology
    • Occupational Health
    • Laboratory Safety

    Background:

    • Zika virus (ZIKV) spread in the Americas (2015) heightened laboratory research and diagnostic testing.
    • This increased the potential for ZIKV exposure among laboratory workers and biomedical researchers.

    Purpose of the Study:

    • To report laboratory-associated Zika virus disease cases in the United States.
    • To emphasize the importance of laboratory biosafety practices.

    Main Methods:

    • Retrospective case reporting of laboratory-associated Zika virus disease.
    • Review of case details including exposure routes.

    Main Results:

    • Four cases of laboratory-associated Zika virus disease were reported in the US between 2016-2019.
    • Two cases were linked to needlestick injuries; the transmission route for the other two cases was undetermined.

    Conclusions:

    • Laboratory work with Zika virus presents a risk of infection to personnel.
    • Implementation and adherence to good laboratory biosafety practices are essential to mitigate infection risks.
    Keywords:
    Zika virusflaviviruslaboratorymosquito-borne diseasesneedlestickoccupationalvector-borne diseasesviruseszoonoses

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