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Differential mood changes following basal ganglia vs thalamic lesions
S E Starkstein1, R G Robinson, M L Berthier
1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Archives of Neurology
|July 1, 1988
Abstract:
Patients with computed tomographic scan-verified unilateral lesions in the basal ganglia or thalamus were examined for the presence of poststroke mood disorders. Patients with left-sided basal ganglia lesions (mainly in the head of the caudate nucleus) showed a significantly higher frequency and severity of depression, as compared with patients with right-sided basal ganglia or thalamic (left- or right-sided) lesions. Results suggest that damage to biogenic amine pathways and/or frontocaudate projections may play an important role in the modulation of mood.