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Related Experiment Videos

The pattern electroretinogram (PERG) in ocular hypertension and glaucoma.

G W Weinstein1, G B Arden, R A Hitchings

  • 1Moorfields Eye Hospital, London.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 1, 1988
PubMed
Summary

The pattern electroretinogram (PERG) can detect early optic nerve damage in glaucoma. A specific wave in the PERG is reduced in patients with early glaucoma and ocular hypertension.

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Optic nerve damage can occur before vision changes are noticeable.
  • The pattern electroretinogram (PERG) measures the electrical response of the retina to visual stimuli.

Purpose of the Study:

  • To investigate the utility of PERG in detecting early optic nerve dysfunction in glaucoma and ocular hypertension.
  • To compare PERG results in patients with early glaucoma and ocular hypertension to those of normal subjects.

Main Methods:

  • Subjects with early glaucoma and ocular hypertension underwent PERG testing.
  • PERG results were analyzed for specific wave components, particularly the second negative wave.
  • Data were compared between patient groups and a control group of normal subjects.

Main Results:

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  • A selective reduction in the second negative wave of the PERG was observed in patients with evidence of optic nerve dysfunction.
  • This reduction was present even in early stages of glaucoma and ocular hypertension.
  • The findings suggest the second negative wave is a sensitive indicator of optic nerve health.

Conclusions:

  • The PERG, specifically the second negative wave, shows promise as an early diagnostic tool for glaucoma and ocular hypertension.
  • PERG may help identify individuals with ocular hypertension at risk of developing visual field loss.
  • This technique could aid in timely medical or surgical intervention to prevent vision impairment.