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Correlations between cis-platinum dosage and toxicity in a guinea pig model

L J Hoeve1, I R Mertens zur Borg, M Rodenburg

  • 1ENT Department, Erasmus University, Rotterdam, The Netherlands.

Archives of Oto-Rhino-Laryngology
|January 1, 1988
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...