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Potential association between elevated serum human epididymis protein 4 and chronic kidney disease in female patients

Z-J Meng1, X-J Li2, F Liu1

  • 1Department of Clinical Laboratory, Affiliated People's Hospital of Shanxi Medical University, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|April 26, 2021
PubMed

Insights

Serum levels of human epididymis protein 4 (HE4) are elevated in women with chronic kidney disease (CKD). This study suggests HE4 is a promising biomarker for diagnosing and staging CKD in Han Chinese females.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Clinical Chemistry

Background:

  • Elevated serum human epididymis protein 4 (HE4) observed in chronic kidney disease (CKD).
  • Uncertainty regarding HE4's utility as a diagnostic biomarker for CKD.

Purpose of the Study:

  • To investigate serum HE4 as a potential biomarker for CKD diagnosis in Han Chinese females.
  • To evaluate HE4's diagnostic and staging value compared to established renal function markers.

Main Methods:

  • Cross-sectional study involving 347 Han Chinese females (154 healthy controls, 193 with CKD).
  • Measurement of serum HE4, creatinine (Scr), beta2-microglobulin (B2M), and cystatin C (CysC).
  • Statistical analysis including ROC curve analysis for diagnostic accuracy.

Main Results:

  • Significantly higher serum HE4 levels in CKD patients compared to controls (P < 0.001).
  • Significant differences in HE4 levels across CKD subgroups (P < 0.001).
  • HE4 demonstrated superior diagnostic value over other tested indicators via ROC analysis.

Conclusions:

  • Serum HE4 shows potential as a biomarker for CKD diagnosis in Han Chinese females.
  • HE4 may also be valuable for assessing CKD staging.
  • Further research is warranted to confirm HE4's clinical utility in CKD management.

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