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Association of Viruses in the Development of Cardiovascular Diseases

Bisma Rauff1, Arif Malik2, Yasir A Bhatti3

  • 1Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW Sydney, Australia.

Current Pharmaceutical Design
|April 27, 2021
PubMed

Insights

Inflammatory cardiomyopathy, a type of cardiovascular disease (CVD), involves heart inflammation and has diverse causes like infections and toxins. This review covers myocarditis, inflammatory cardiomyopathy, and atherosclerosis, focusing on virus-associated cardiac conditions.

Area of Science:

  • Cardiology
  • Immunology
  • Infectious Diseases

Background:

  • Cardiovascular diseases (CVD), particularly inflammatory cardiomyopathy, involve myocardial inflammation with a high risk of heart dysfunction.
  • Etiologies are diverse, including viral, protozoal, fungal, and bacterial infections, alongside drug toxicity and systemic autoimmune diseases.

Purpose of the Study:

  • To review current evidence on the types, pathogenesis, and treatment of myocarditis, inflammatory cardiomyopathy, and atherosclerosis.
  • To specifically highlight virus-associated cardiac diseases and their role in disease progression.

Main Methods:

  • Comprehensive literature review of existing evidence.
  • Analysis of pathogen roles, host genetics, and environmental factors in disease progression.

Main Results:

  • Inflammatory cardiomyopathy presents a poor prognosis despite extensive research.
  • The roles of various triggers, including viral agents (as inducers or bystanders), are still under investigation.

Conclusions:

  • Understanding the complex interplay of factors in inflammatory cardiomyopathy is crucial for improving outcomes.
  • Further research into virus-associated cardiac diseases may offer new therapeutic targets.

Keywords:
COVID-19HSV-1 and 2cardioviruscoxsackieviruscytomegalovirusechovirushepatitis virusesinfluenza viruses.parvovirus B19

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