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Updated: Jun 28, 2026
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrin Based Nanosponges: A Multidimensional Drug Delivery System and its Biomedical Applications
Preeti Tanaji Mane1, Balaji Sopanrao Wakure2, Pravin Shridhar Wakte1
1University Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra,India.
Current Drug Delivery
|April 27, 2021
Summary
Cyclodextrin nanosponges are versatile nanocarriers for drug delivery. These hypercrosslinked polymers enhance drug solubility, bioavailability, and stability, with potential for targeted delivery and diverse pharmaceutical applications.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Cyclodextrin nanosponges are advanced nanocarriers with a 3D mesh-like structure.
- They are synthesized from hypercrosslinked cyclodextrin polymers, offering tunable properties via crosslinker selection.
Purpose of the Study:
- To highlight the potential of cyclodextrin nanosponges as drug delivery systems.
- To explore their application in enhancing solubility, bioavailability, and stability of various drug molecules.
- To discuss their utility in co-delivery, targeted delivery, and development of nanodiagnostics and nanosensors.
Main Methods:
- Fabrication of nanosponges using different crosslinkers and polymer ratios.
- Encapsulation of diverse drug molecules (hydrophilic, lipophilic, small, and large).
- Surface modification with ligands for targeted drug delivery.
Main Results:
- Demonstrated ability to encapsulate a wide range of drug molecules.
- Significant improvements in drug solubility, bioavailability, and stability.
- Potential for co-delivery and targeted drug delivery applications.
- Versatility shown for delivering proteins, enzymes, natural compounds, and gases.
Conclusions:
- Cyclodextrin nanosponges offer a flexible platform for drug delivery, addressing challenges with complex molecules.
- Their tunable nature and broad applicability suggest a promising future in pharmaceutical products.
- Further research is expanding their use into diagnostics, sensors, and biomaterials.
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