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Benign breast disease and changes in mammographic breast density
Laura L Reimers1, Mandy Goldberg1, Parisa Tehranifar1,2
1Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Breast Cancer Research : BCR
|April 27, 2021
Summary
Women with benign breast disease (BBD) have higher mammographic breast density (MBD). This association is strongest when BBD is diagnosed before a woman
Area of Science:
- Oncology
- Radiology
- Epidemiology
Background:
- Mammographic breast density (MBD) and benign breast disease (BBD) are significant breast cancer risk factors.
- Understanding MBD trends in relation to BBD, age, and parity is crucial for breast cancer prevention and management.
Purpose of the Study:
- To investigate the association between benign breast disease (BBD) and mammographic breast density (MBD).
- To examine how parity influences the relationship between BBD and MBD.
Main Methods:
- Utilized data from the prospective Early Determinants of Mammographic Density (EDMD) study.
- Analyzed MBD (percent density, dense area, non-dense area) in 676 women using computer-assisted methods.
- Employed linear regression with generalized estimating equations to assess associations between self-reported BBD and MBD.
Main Results:
- Women with a history of BBD exhibited higher MBD compared to those without BBD.
- The association between BBD and increased MBD was significant for nulliparous women and those diagnosed before their first birth.
- No significant difference in MBD was observed for women diagnosed with BBD after their first birth.
Conclusions:
- Self-reported BBD is linked to elevated mammographic breast density.
- The heightened MBD associated with BBD is particularly relevant for women diagnosed prior to their first childbirth.
