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Lymphatic malformations adjacent to the airway in neonates: Risk factors for outcome
Frédérique C M Bouwman1, Willemijn M Klein2, Ivo de Blaauw3
1Department of Pediatric Surgery, Radboudumc-Amalia Children's Hospital, Nijmegen, Netherlands; Department of Radiology and Nuclear Medicine, division of Pediatric Radiology, Radboudumc-Amalia Children's Hospital, Nijmegen, Netherlands.
Purpose:
To evaluate imaging, treatment, and outcomes in neonates with a lymphatic malformation (LM) adjacent to the airway and to evaluate risk factors that can predict outcome.
Methods:
A retrospective case series was conducted of ten patients treated between January 2011 and July 2019. The main outcome measures included airway compromise and clinical response to sclerotherapy ± surgery. Categorical data were compared using the Fisher's exact test.
Results:
Ex-utero intrapartum therapy was performed in four cases, among whom one died due to sepsis. All patients underwent schlerotherapy, with surgical debulking in two. Four patients showed a good clinical response, and five started experimental systemic treatment. Patients with bilateral disease and patients with an LM with >180° tracheal surrounding were significantly at risk for airway compromise (bilateral: n = 6/6 versus n = 0/4, p = 0.005; >180°: n = 5/5 versus n = 1/5, p = 0.048). The need for LM treatment in the neonatal period was indicative of a poor clinical response ('non-responders' 5/6, 'responders' 0/4; p = 0.048).
Conclusions:
This study indicates that bilateral disease and >180° tracheal surrounding are risk factors for airway compromise in neonates with an LM adjacent to the airway. In addition, the need for early treatment seems to be indicative of a poor clinical response.
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