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Published on: May 30, 2025
CBD, a precursor of THC in e-cigarettes
Zsuzsanna Czégény1, Gréta Nagy1, Bence Babinszki1
1Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar tudósok körútja 2, Budapest, 1117, Hungary.
Heating cannabidiol (CBD) in e-cigarettes produces THC, the psychoactive compound in cannabis. This study reveals CBD acts as a precursor to THC, posing health risks associated with THC exposure from vaping.
Area of Science:
- Chemistry
- Toxicology
- Materials Science
Background:
- Cannabidiol (CBD) is widely used in e-cigarettes.
- Limited research exists on CBD pyrolysis products under typical vaping conditions.
Purpose of the Study:
- To investigate the effect of temperature on CBD pyrolysis products.
- To analyze CBD transformation under inert and oxidative conditions relevant to e-cigarette use.
Main Methods:
- Pyrolysis experiments conducted from 250-500°C.
- Analysis of pyrolysis products using Gas Chromatography-Mass Spectrometry (GC-MS).
Main Results:
- CBD transforms into other substances, including THC, cannabinol, and cannabichromene.
- THC was the predominant pyrolysis product across all tested temperatures and atmospheres.
- 25-52% of CBD was converted to other chemical substances depending on conditions.
Conclusions:
- CBD in e-cigarettes can convert to THC, a psychoactive compound.
- CBD vaping carries risks associated with THC exposure.
- Findings contribute to understanding the safety profile of CBD e-cigarettes.
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