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Isolated Lung Perfusion System in the Rabbit Model
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Ex vivo lung perfusion made easy
Prashant N Mohite1, Kabeer Umakumar1, Olaf Maunz1
1Royal Brompton and Harefield NHS Foundation Trust Hill End Road, Harefield, Uxbridge, London, UB9 6JH.
Multimedia Manual of Cardiothoracic Surgery : MMCTS
|April 27, 2021
Summary
Ex vivo lung perfusion assesses and improves donor lungs for transplant, expanding the donor pool. This technique offers a systematic method to evaluate and treat lungs, increasing transplant viability.
Area of Science:
- Cardiovascular and Respiratory System Physiology
- Transplant Surgery Techniques
- Organ Preservation and Assessment
Background:
- Lung transplantation faces a limited donor organ supply.
- Suboptimal donor lungs are often discarded.
- Ex vivo lung perfusion (EVLP) offers a potential solution.
Observation:
- EVLP allows for systematic assessment of donor lung viability.
- Therapeutic interventions can be administered during EVLP.
- Low-molecular-weight perfusate is utilized for lung treatment.
Findings:
- The study provides a stepwise protocol for performing EVLP.
- Criteria for accepting lungs for transplant after EVLP are detailed.
- EVLP demonstrates utility in improving and assessing marginal donor lungs.
Implications:
- EVLP can significantly increase the utilization of donor lungs.
- This technique enhances the chances of successful lung transplant outcomes.
- EVLP is a crucial tool for modern lung transplant programs.
