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Related Experiment Video

Updated: Nov 8, 2025

Isolated Lung Perfusion System in the Rabbit Model
10:18

Isolated Lung Perfusion System in the Rabbit Model

Published on: July 15, 2021

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Ex vivo lung perfusion made easy.

Prashant N Mohite1, Kabeer Umakumar1, Olaf Maunz1

  • 1Royal Brompton and Harefield NHS Foundation Trust Hill End Road, Harefield, Uxbridge, London, UB9 6JH.

Multimedia Manual of Cardiothoracic Surgery : MMCTS
|April 27, 2021
PubMed
Summary

Ex vivo lung perfusion assesses and improves donor lungs for transplant, expanding the donor pool. This technique offers a systematic method to evaluate and treat lungs, increasing transplant viability.

Keywords:
Ex vivo lung perfusionLung donationLung transplant

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Area of Science:

  • Cardiovascular and Respiratory System Physiology
  • Transplant Surgery Techniques
  • Organ Preservation and Assessment

Background:

  • Lung transplantation faces a limited donor organ supply.
  • Suboptimal donor lungs are often discarded.
  • Ex vivo lung perfusion (EVLP) offers a potential solution.

Observation:

  • EVLP allows for systematic assessment of donor lung viability.
  • Therapeutic interventions can be administered during EVLP.
  • Low-molecular-weight perfusate is utilized for lung treatment.

Findings:

  • The study provides a stepwise protocol for performing EVLP.
  • Criteria for accepting lungs for transplant after EVLP are detailed.
  • EVLP demonstrates utility in improving and assessing marginal donor lungs.

Implications:

  • EVLP can significantly increase the utilization of donor lungs.
  • This technique enhances the chances of successful lung transplant outcomes.
  • EVLP is a crucial tool for modern lung transplant programs.