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Melanoma brain metastases in Ireland: surgical and systemic considerations
Philip J O'Halloran1,2, Anna Cleary2, Jane B Cryan3
1National Neurosurgery Center, Beaumont Hospital, Dublin, Ireland.
Background:
Cerebral metastases is a common complication in patients with melanoma. There is a paucity of information in the Republic of Ireland regarding the factors associated with melanoma brain metastases (MBM).
Methods:
Patients diagnosed with melanoma brain metastases in Ireland were retrospectively identified in Beaumont Hospital between 1999 and 2018. Patient demographics; age at diagnosis of primary melanoma, age at detection of MBM, year of detection of MBM, anatomical location of primary melanoma, BRAF mutation analysis and the number of metastases were investigated. Follow-up data were also derived, including overall survival.
Results:
There has being a 158% increase in the incidence of primary melanoma from 1999 compared to 2016. Over the same time period 128 patients with melanoma brain metastases were diagnosed. There was a significant male predominance (n = 77/128; 60%; p < 0.0001). BRAF mutation and leptomeningeal disease were independent prognostic factors in our cohort with a median survival 8 months and 0.5 months, respectively.
Conclusions:
Male predominance, leptomeningeal disease and BRAF mutation represent important considerations in this population group. The results of this study add to our knowledge concerning outcomes in melanoma brain metastases and may be useful in clinical planning and future treatments.
Insights
Melanoma brain metastases (MBM) disproportionately affect males and are linked to BRAF mutations and leptomeningeal disease, impacting survival. This study highlights key factors for clinical planning in Ireland.
Area of Science:
- Oncology
- Dermatology
- Neurology
Background:
- Cerebral metastases are a frequent complication in melanoma patients.
- Limited data exists in Ireland on factors influencing melanoma brain metastases (MBM).
Purpose of the Study:
- To investigate factors associated with melanoma brain metastases in Ireland.
- To analyze patient demographics, primary melanoma characteristics, and survival outcomes.
Main Methods:
- Retrospective analysis of 128 patients diagnosed with MBM at Beaumont Hospital (1999-2018).
- Investigation of patient demographics, primary melanoma site, BRAF mutation status, and number of metastases.
- Analysis of follow-up data, including overall survival.
Main Results:
- A 158% increase in primary melanoma incidence from 1999 to 2016.
- Significant male predominance (60%) in MBM patients.
- BRAF mutation and leptomeningeal disease were independent prognostic factors, with median survival of 8 and 0.5 months, respectively.
Conclusions:
- Male predominance, leptomeningeal disease, and BRAF mutation are critical factors in MBM.
- Findings enhance understanding of MBM outcomes and aid clinical planning and treatment strategies.
