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Updated: Nov 8, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête
M L Koloko Ngassie1, C A Brandsma1, R Gosens2
1University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
Abstract:
Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.
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