Related Experiment Video
Updated: Nov 8, 2025
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
100
Targeting microRNAs by curcumin: implication for cancer therapy.
Fatemeh Sadoughi1, Parisa Maleki Dana1, Zatollah Asemi1
1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
Critical Reviews in Food Science and Nutrition
|April 27, 2021
Summary
Curcumin, a plant compound, impacts cancer by altering microRNA (miRNA) expression, offering potential for targeted cancer therapy. This review explores curcumin
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Despite advances in cancer therapy, natural compounds like curcumin show promise.
- Curcumin, a polyphenol, possesses anticancer properties.
- MicroRNAs (miRNAs) are key regulators of gene expression and cellular processes relevant to cancer.
Purpose of the Study:
- To review how curcumin influences cancer hallmarks via miRNA modulation.
- To assess curcumin's potential as an alternative or adjunct to chemotherapy.
Main Methods:
- Literature review of studies on curcumin, miRNAs, and cancer.
- Analysis of curcumin's molecular mechanisms targeting miRNA pathways.
- Evaluation of evidence for curcumin's efficacy in preclinical and clinical cancer models.
Main Results:
- Curcumin modulates the expression of specific miRNAs involved in cancer progression.
- These miRNA changes affect cancer hallmarks including proliferation, apoptosis, and metastasis.
- Curcumin's effects on miRNAs present a novel avenue for cancer treatment strategies.
Conclusions:
- Curcumin's ability to regulate miRNAs provides a mechanism for its anticancer effects.
- Curcumin holds potential as a targeted therapy, possibly complementing or replacing chemotherapy.
- Further research is warranted to fully elucidate curcumin-miRNA interactions for clinical application.
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