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Multiple interactions between melatonin and non-coding RNAs in cancer biology
Masomeh Maleki1, Nafiseh Khelghati2, Forough Alemi1
1Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
Chemical Biology & Drug Design
|April 27, 2021
Summary
This study explores how long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) influence the hormone melatonin. Understanding these interactions provides a foundation for future research into melatonin
Area of Science:
- Endocrinology
- Molecular Biology
- Genetics
Background:
- Melatonin, a hormone from the pineal gland, regulates growth, circadian rhythms, and exhibits antioxidant, anti-tumor, and anti-ischemia properties.
- Melatonin interacts with proteins and also influences regulatory RNAs, specifically long non-coding RNAs (lncRNAs) and microRNAs (miRNAs).
Purpose of the Study:
- To provide an overview of physiological and pathological conditions that affect melatonin levels via lncRNA and miRNA.
- To establish a foundation for future mechanistic studies on melatonin's role in non-coding RNA regulation.
Main Methods:
- Literature review and synthesis of existing research on melatonin, lncRNAs, and miRNAs.
- Analysis of studies detailing the interplay between melatonin and non-coding RNAs in various conditions.
Main Results:
- Identified key lncRNAs and miRNAs involved in modulating melatonin's physiological and pathological effects.
- Highlighted the complex regulatory network connecting melatonin with the non-coding transcriptome.
Conclusions:
- Melatonin's functions are significantly influenced by lncRNAs and miRNAs.
- Further research into these interactions can elucidate novel therapeutic strategies targeting the non-coding transcriptome for melatonin-related conditions.
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