Related Experiment Video

Updated: Nov 8, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

807

Multiple interactions between melatonin and non-coding RNAs in cancer biology

Masomeh Maleki1, Nafiseh Khelghati2, Forough Alemi1

  • 1Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.

Chemical Biology & Drug Design
|April 27, 2021
PubMed

Insights

This study explores how long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) influence the hormone melatonin. Understanding these interactions provides a foundation for future research into melatonin

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Melatonin, a hormone from the pineal gland, regulates growth, circadian rhythms, and exhibits antioxidant, anti-tumor, and anti-ischemia properties.
  • Melatonin interacts with proteins and also influences regulatory RNAs, specifically long non-coding RNAs (lncRNAs) and microRNAs (miRNAs).

Purpose of the Study:

  • To provide an overview of physiological and pathological conditions that affect melatonin levels via lncRNA and miRNA.
  • To establish a foundation for future mechanistic studies on melatonin's role in non-coding RNA regulation.

Main Methods:

  • Literature review and synthesis of existing research on melatonin, lncRNAs, and miRNAs.
  • Analysis of studies detailing the interplay between melatonin and non-coding RNAs in various conditions.

Main Results:

  • Identified key lncRNAs and miRNAs involved in modulating melatonin's physiological and pathological effects.
  • Highlighted the complex regulatory network connecting melatonin with the non-coding transcriptome.

Conclusions:

  • Melatonin's functions are significantly influenced by lncRNAs and miRNAs.
  • Further research into these interactions can elucidate novel therapeutic strategies targeting the non-coding transcriptome for melatonin-related conditions.
Keywords:
MelatonincancerlncRNAmiRNA

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.0K
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.6K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.8K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K