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Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

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Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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Accessory Structures of the Skin: Hair and Hair Follicles01:16

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Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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From Hair to Healing: Follicular Unit Transplantation for Chronic Ulcer Management-A Case Series.

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Resident T cell activation leads to human hair follicle immune privilege loss <i>ex vivo</i>, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata.

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Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo.

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Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
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Hair transplantation: Basic overview.

Francisco Jimenez1, Majid Alam2, James E Vogel3

  • 1Mediteknia Dermatology and Hair Transplant Clinic, Universidad Fernando Pessoa Canarias, Gran Canaria, Spain.

Journal of the American Academy of Dermatology
|April 27, 2021
PubMed
Summary
This summary is machine-generated.

This review details the evolution of follicular unit transplantation for hair restoration surgery. It guides dermatologists in identifying suitable candidates for hair loss treatment and discusses surgical indications.

Keywords:
FUEandrogenetic alopeciafollicular unitfollicular unit excisionhair folliclehair graftinghair transplantationscarring alopeciastrip harvesting

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Area of Science:

  • Dermatology
  • Surgical Techniques
  • Hair Restoration Science

Background:

  • Follicular unit transplantation is the cornerstone of modern hair restoration surgery.
  • Understanding scalp follicular unit anatomy is crucial for dermatologists.
  • Androgenetic alopecia and female pattern hair loss are primary concerns.

Purpose of the Study:

  • To review the historical evolution of hair transplantation techniques.
  • To discuss the anatomical concepts of scalp follicular units.
  • To provide guidelines for selecting hair transplant candidates.

Main Methods:

  • Literature review of hair transplantation techniques and evolution.
  • Discussion of scalp follicular unit morphology and distribution.
  • Analysis of conditions suitable and unsuitable for surgical hair restoration.

Main Results:

  • Hair transplantation techniques have significantly evolved.
  • Specific anatomical knowledge of follicular units is essential.
  • Clear criteria exist for identifying good and poor candidates for surgery.

Conclusions:

  • Follicular unit transplantation is the standard for hair restoration.
  • Dermatologists require specific knowledge to guide patient selection.
  • Surgical intervention is indicated for specific hair loss conditions.