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Updated: Nov 8, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Targeted therapy in Xp11 translocation renal cell carcinoma
Translocation renal cell carcinoma (TRCC) is a rare cancer. Tyrosine-kinase inhibitors showed effectiveness in a patient with TRCC, suggesting potential for targeted therapies in this rare malignancy.
Area of Science:
- Oncology
- Genetics
- Rare Cancers
Background:
- Translocation renal cell carcinoma (TRCC) is a rare subtype of kidney cancer, primarily affecting young individuals.
- TRCC is characterized by specific chromosomal translocations on chromosome X, involving the transcription factor E3 gene.
- This rare cancer accounts for only 1-5% of all renal cell carcinomas.
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