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Updated: Nov 8, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

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Device-Related Thrombosis in Patients Receiving One-Stop Intervention for Nonvalvular Atrial Fibrillation: A Systemic

Li-Xing Hu1,2, Min Tang1,2, Jing-Tao Zhang1,2

  • 1State Key Laboratory of Cardiovascular Disease, Department of Cardiovascular Medicine,  The Cardiac Arrhythmia Center, Fuwai Hospital, Beijing, People's Republic of China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|April 28, 2021
PubMed

Insights

Device-related thrombus (DRT) is an uncommon complication after combined catheter ablation and left atrial appendage occlusion, occurring early post-procedure. Anticoagulation effectively resolves most DRT cases.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Catheter ablation and percutaneous left atrial appendage occlusion are common procedures.
  • Device-related thrombus (DRT) is a potential complication.
  • Understanding DRT in combined interventions is crucial for patient safety.

Purpose of the Study:

  • To assess the incidence, clinical implications, and treatment of DRT after combined catheter ablation and LAAO.
  • To provide insights into DRT management strategies.

Main Methods:

  • Meta-analysis of observational studies.
  • Inclusion of 21 studies (3 multi-center, 18 single-center registries) and 1 case report.
  • Pooled incidence calculation and analysis of DRT characteristics and outcomes.

Main Results:

  • Pooled DRT incidence was 1.2% (18/1,708) in one-stop interventions.
  • Most DRT events (56.25%) were diagnosed within 3 months post-procedure.
  • Anticoagulation treatment led to complete thrombus resolution in 63% of cases.

Conclusions:

  • DRT is an uncommon but significant complication of combined procedures.
  • Early diagnosis and anticoagulation are key management strategies.
  • Further research is needed to understand unknown clinical events related to DRT.

Keywords:
atrial fibrillationcatheter ablationdevice-related thrombosisleft atrial appendage occlusion

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