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Feeding intolerance during phototherapy in preterm infants

Carlo Dani1,2, Martina Ciarcià2, Michele Luzzati2

  • 1Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|April 28, 2021
PubMed

Insights

Phototherapy (PT) for hyperbilirubinemia in preterm infants can cause feeding intolerance. This intolerance was transient in about half of infants, resolving after PT completion, suggesting a temporary effect.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology

Background:

  • Hyperbilirubinemia is common in very preterm infants.
  • Phototherapy (PT) is a standard treatment for neonatal hyperbilirubinemia.
  • PT may negatively impact gut perfusion, potentially leading to feeding intolerance.

Purpose of the Study:

  • To evaluate the occurrence of feeding intolerance in very preterm infants undergoing PT.
  • To assess the duration and resolution of feeding intolerance related to PT.

Main Methods:

  • Retrospective study of 125 preterm infants (25+0-31+6 weeks gestation).
  • Infants served as their own controls, monitoring feeding intolerance before, during, and after PT.
  • Regression analysis was used to identify risk factors.

Main Results:

  • 46% of infants developed feeding intolerance during PT.
  • 81% of those with feeding intolerance recovered tolerance after PT cessation.
  • Higher birth weight and age at PT initiation showed a non-significant trend toward reduced risk.

Conclusions:

  • Transient feeding intolerance is common in very preterm infants receiving PT.
  • Feeding intolerance typically resolves after PT is completed.
  • Further research is needed to confirm the PT-feeding intolerance correlation.
Abstract

Keywords:
Feeding intolerancejaundicephototherapypreterm infant

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