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Feeding intolerance during phototherapy in preterm infants
Carlo Dani1,2, Martina Ciarcià2, Michele Luzzati2
1Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
Summary
Phototherapy (PT) for hyperbilirubinemia in preterm infants can cause feeding intolerance. This intolerance was transient in about half of infants, resolving after PT completion, suggesting a temporary effect.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
Background:
- Hyperbilirubinemia is common in very preterm infants.
- Phototherapy (PT) is a standard treatment for neonatal hyperbilirubinemia.
- PT may negatively impact gut perfusion, potentially leading to feeding intolerance.
Purpose of the Study:
- To evaluate the occurrence of feeding intolerance in very preterm infants undergoing PT.
- To assess the duration and resolution of feeding intolerance related to PT.
Main Methods:
- Retrospective study of 125 preterm infants (25+0-31+6 weeks gestation).
- Infants served as their own controls, monitoring feeding intolerance before, during, and after PT.
- Regression analysis was used to identify risk factors.
Main Results:
- 46% of infants developed feeding intolerance during PT.
- 81% of those with feeding intolerance recovered tolerance after PT cessation.
- Higher birth weight and age at PT initiation showed a non-significant trend toward reduced risk.
Conclusions:
- Transient feeding intolerance is common in very preterm infants receiving PT.
- Feeding intolerance typically resolves after PT is completed.
- Further research is needed to confirm the PT-feeding intolerance correlation.
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