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Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for

Dawn G L Thean1, Alan S L Wong2

  • 1Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Neural Regeneration Research
|April 28, 2021
PubMed
Summary

No abstract available in PubMed .

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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