Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

48.3K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
48.3K
Auditory Pathway01:15

Auditory Pathway

6.2K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
6.2K
Hearing01:31

Hearing

54.9K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
54.9K
Feedback Inhibition00:46

Feedback Inhibition

56.0K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin.

bioRxiv : the preprint server for biology·2026
Same author

Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.

The Journal of biological chemistry·2026
Same author

Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta-Analysis.

Stroke (Hoboken, N.J.)·2026
Same author

Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.

Structure (London, England : 1993)·2025
Same author

Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.

bioRxiv : the preprint server for biology·2025
Same author

Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.

Structure (London, England : 1993)·2025
Same journal

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026
Same journal

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026
Same journal

Transient distortions of the South Atlantic Anomaly radiation environments driven by electric fields.

Nature communications·2026
Same journal

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Nature communications·2026
Same journal

Structural and mechanistic insights into primer synthesis initiation by DNA primase.

Nature communications·2026
Same journal

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Nov 8, 2025

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.0K

Efferent feedback controls bilateral auditory spontaneous activity.

Yixiang Wang1, Maya Sanghvi1, Alexandra Gribizis1,2

  • 1Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.

Nature Communications
|April 28, 2021
PubMed
Summary
This summary is machine-generated.

The brain

More Related Videos

Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

14.8K
A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds
10:13

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds

Published on: November 26, 2012

14.5K

Related Experiment Videos

Last Updated: Nov 8, 2025

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.0K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

14.8K
A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds
10:13

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds

Published on: November 26, 2012

14.5K

Area of Science:

  • Neuroscience
  • Auditory System Development
  • Sensory Neuroscience

Background:

  • Spontaneous activity in the developing auditory system is crucial for neural circuit formation.
  • The influence of peripheral firing patterns on central auditory spontaneous activity remains unclear.

Purpose of the Study:

  • To investigate the role of efferent pathways in shaping spontaneous activity in the developing auditory system.
  • To understand how efferent modulation impacts bilateral auditory circuit development and function.

Main Methods:

  • Utilized knockout models targeting α9/α10 nicotinic acetylcholine receptors.
  • Employed pharmacological and chemogenetic techniques to manipulate efferent system activity.
  • Recorded and analyzed spontaneous neural activity patterns in the auditory system.

Main Results:

  • Identified widespread bilateral coupling of spontaneous activity during efferent modulation.
  • Demonstrated that knockout of α9/α10 nicotinic acetylcholine receptors significantly reduces bilateral correlations.
  • Showed that the efferent system is essential for normal bilateral coupling of spontaneous activity.
  • Found reduced auditory sensitivity at hearing onset in the absence of pre-hearing efferent modulation.

Conclusions:

  • Afferent and efferent pathways collaboratively shape spontaneous activity patterns in the developing auditory system.
  • Efferent pathways play a critical role in coordinating bilateral spontaneous activity.
  • Pre-hearing efferent modulation is vital for the emergence of functional auditory responses.