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Effectiveness of Image-Guided Radiotherapy in Adjuvant Radiotherapy on Survival for Localized Breast Cancer: A
Ji-An Liang1,2, Po-Chang Lee3, Chun-Ping Ku3
1Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.
Cancer Management and Research
|April 28, 2021
Summary
Image-guided radiotherapy (IGRT) did not significantly improve overall survival for localized breast cancer (LBC) patients receiving adjuvant conventional fractionated radiotherapy (CFRT). Further randomized trials are needed to confirm these findings in breast cancer treatment.
Area of Science:
- Oncology
- Radiotherapy
- Medical Physics
Background:
- Image-guided radiotherapy (IGRT) enhances radiotherapy precision.
- Adjuvant conventional fractionated radiotherapy (CFRT) is a standard treatment for localized breast cancer (LBC).
Purpose of the Study:
- To compare overall survival (OS) in LBC patients treated with adjuvant CFRT, with or without IGRT.
- To evaluate the impact of IGRT on survival outcomes in LBC patients.
Main Methods:
- Population-based analysis of LBC patients diagnosed between 2011-2013 from the Taiwan Cancer Registry.
- Propensity score (PS) weighting used to balance confounders between IGRT and non-IGRT groups.
- Hazard ratios (HR) for death and other outcomes were compared.
Main Results:
- Analysis included 6490 patients with balanced covariates post-PS weighting.
- HR for death with IGRT vs. non-IGRT was 1.02 (95% CI 0.80-1.31, P=0.86), showing no significant difference.
- Supplementary analyses also revealed no significant differences in outcomes.
Conclusions:
- Adjuvant CFRT for LBC showed no statistically significant difference in OS between patients treated with or without IGRT.
- This study is the first to investigate this comparison, highlighting the need for randomized controlled trials to validate the findings.
