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Updated: Nov 8, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Hybrid coronary revascularization vs. percutaneous coronary interventions for multivessel coronary artery disease
Edward L Hannan1, Yi-Feng Wu1, Kimberly Cozzens1
1University at Albany, State University of New York, Albany, NY, USA.
Insights
Hybrid coronary revascularization (HCR) and percutaneous coronary intervention (PCI) showed similar long-term survival for multivessel disease. HCR reduced repeat revascularization in the left anterior descending artery, suggesting improved graft longevity.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Health Services Research
Background:
- Hybrid coronary revascularization (HCR) combines minimally invasive surgery for the left anterior descending (LAD) artery with percutaneous coronary intervention (PCI) for other coronary arteries.
- While HCR offers shorter recovery than traditional bypass surgery, its long-term outcomes compared to isolated PCI for multivessel disease are less understood.
Purpose of the Study:
- To compare the long-term efficacy of HCR versus PCI in patients with multivessel coronary artery disease.
- To evaluate differences in mortality and repeat revascularization rates between HCR and PCI strategies.
Main Methods:
- A cohort study utilizing data from New York's cardiac surgery and PCI registries (2010-2016).
- Analysis included 335 HCR patients and 25,557 PCI patients with multivessel coronary artery disease.
- Cox proportional hazards models were employed to adjust for selection bias, with a median follow-up of four years.
Main Results:
- No significant difference in 6-year adjusted survival rates between HCR and PCI groups (83.17% vs. 81.65%).
- HCR patients demonstrated a significantly lower rate of repeat revascularization in the LAD artery (91.13% vs. 83.59%).
Conclusions:
- Hybrid coronary revascularization is infrequently utilized for multivessel coronary artery disease.
- HCR is associated with comparable long-term mortality to PCI but offers reduced rates of repeat revascularization in the LAD artery.
- The improved outcomes for HCR in the LAD artery may be attributed to the superior durability of left arterial mammary grafts.
Objective:
Hybrid coronary revascularization (HCR) combines a minimally invasive surgical approach to the left anterior descending (LAD) artery with percutaneous coronary intervention (PCI) for non-LAD diseased coronary arteries. It is associated with shorter hospital lengths of stay and recovery times than conventional coronary artery bypass surgery, but there is little information comparing it to isolated PCI for multivessel disease. Our objective is to compare long-term outcomes of HCR and PCI for patients with multivessel disease.
Methods:
This cohort study used data from New York's cardiac surgery and PCI registries in 2010-2016 to examine mortality and repeat revascularization rates for patients with multivessel coronary artery disease who underwent HCR and PCI. Cox proportional hazards methods were used to reduce selection bias. Patients were followed for a median of four years.
Results:
There was a total of 335 HCR patients (1.2%) and 25,557 PCI patients (98.8%) after exclusions. There was no difference in 6-year risk adjusted survival between HCR and PCI patients (83.17% vs. 81.65%, adjusted hazard ratio (aHR) = 0.90 (95% CI: 0.67-1.20). However, HCR patients were more likely to be free from repeat revascularization in the LAD artery (91.13% vs. 83.59%, aHR = 0.51 (95% CI: 0.34-0.77)).
Conclusions:
For patients with multi-vessel coronary artery disease, HCR is rarely performed. There are no differences in mortality rates after four years, but HCR is associated with lower repeat revascularization rates in the LAD artery, presumably due to better longevity in left arterial mammary grafts.
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