Related Experiment Video

Updated: Nov 7, 2025

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

9.3K

Does oropharyngeal administration of colostrum reduce morbidity and mortality in very preterm infants? A randomised

Rahul Aggarwal1,2, Nishad Plakkal2, Vishnu Bhat2,3

  • 1Department of Neonatology, Apollo Cradle, Gurgaon, India.

Journal of Paediatrics and Child Health
|April 28, 2021
PubMed

Insights

Oropharyngeal colostrum administration did not reduce death, late-onset sepsis, or necrotising enterocolitis in very preterm infants. This strategy did not significantly impact major neonatal morbidities or mortality outcomes.

Area of Science:

  • Neonatal Medicine
  • Pediatric Critical Care
  • Neonatal Nutrition

Background:

  • Very preterm infants face high risks of mortality and morbidity.
  • Early administration of human milk components is explored to improve neonatal outcomes.
  • Oropharyngeal colostrum therapy is a potential intervention for preterm neonates.

Purpose of the Study:

  • To investigate the efficacy of oropharyngeal colostrum administration in reducing morbidity and mortality in very preterm infants.
  • To assess the impact of this intervention on key neonatal outcomes.

Main Methods:

  • Randomized controlled trial involving 260 neonates (26-31 weeks gestational age).
  • Intervention group received oropharyngeal colostrum; control group received placebo.
  • Primary outcome: composite of death, late-onset sepsis (LOS), or necrotising enterocolitis (NEC).

Main Results:

  • No statistically significant difference in the composite primary outcome between colostrum and placebo groups (33.6% vs 29.7%, P=0.50).
  • Secondary outcomes, including individual morbidities and mortality, were comparable between groups.
  • No significant reduction in death, LOS, or NEC was observed with oropharyngeal colostrum.

Conclusions:

  • Oropharyngeal colostrum administration did not decrease the composite outcome of death, LOS, or NEC in very preterm neonates.
  • The findings align with existing literature suggesting limited benefit of this specific intervention.
  • Further research may be needed to explore alternative or refined strategies for colostrum utilization in preterm infants.
Abstract

Keywords:
colostrumlate onset sepsisnecrotizing enterocolitisoropharyngealpreterm

More Related Videos

Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

20.1K
Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.4K

Related Concept Videos

Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
56
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
41
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
71
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
665
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
69