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Related Experiment Video

Updated: Nov 7, 2025

Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques
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NexusLIMS: A Laboratory Information Management System for Shared-Use Electron Microscopy Facilities.

Joshua A Taillon1, Thomas F Bina2,3, Raymond L Plante3

  • 1Office of Data and Informatics, Material Measurement Laboratory, National Institute of Standards and Technology, Boulder, CO80305, USA.

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
|April 28, 2021
PubMed
Summary

NexusLIMS is a new laboratory information management system for electron microscopy facilities. It simplifies data management by automatically collecting experimental details, making research data easily searchable and accessible.

Keywords:
data managementelectron microscopylaboratory information managementmetadata extractionopen source softwareuser facility

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Area of Science:

  • Materials Science
  • Scientific Computing
  • Data Management

Background:

  • Electron microscopy facilities generate vast amounts of complex experimental data.
  • Managing and accessing this data efficiently is crucial for multi-user research co-ops.
  • Existing systems often require significant user input and behavioral changes.

Purpose of the Study:

  • To introduce NexusLIMS, a novel laboratory information management system tailored for electron microscopy.
  • To provide a robust solution for managing experimental data in a multi-user research environment.
  • To establish a standardized metadata schema (Nexus Experiment schema) for electron microscopy data.

Main Methods:

  • Development of a custom software package for automated data harvesting and metadata generation.
  • Implementation of a network infrastructure and shared IT resources.
  • Creation of a web-based interface for intuitive data access and exploration.
  • Adherence to existing organizational workflows to minimize user disruption.

Main Results:

  • NexusLIMS successfully integrates data from multiple sources, creating comprehensive experimental metadata records.
  • The system utilizes the new Nexus Experiment schema for standardized data representation.
  • A user-friendly web interface allows for efficient searching and browsing of research data.
  • The system requires minimal user input, adapting to existing procedures.

Conclusions:

  • NexusLIMS offers an effective solution for managing electron microscopy data in shared facilities.
  • The system's design emphasizes automation and minimal user intervention for enhanced usability.
  • The modular codebase is publicly available, promoting wider adoption and adaptation by other research institutions.